The prevalence of diabetes is increasing worldwide and impaired wound healing is a pivotal event responsible for a large number of deaths associated with diabetes. Therefore, a detailed understanding of the wound healing process and methods to improve this knowledge will be of great importance to develop new therapies. The major roadblock, however, in the development of new therapy is the lack of knowledge of the molecular mechanisms responsible for impaired wound healing.
Research at the Amrita School of Biotechnology has recently elucidated a novel role for two potential natural product lead molecules, Anacardic acid and Ecdysterone, to facilitate and enhance the wound healing process through a direct modulation of Matrix metalloproteinase 2 and 9 activity and Epidermal Growth Factor Receptor – ERK 1/2 – Nitric Oxide interaction, respectively. Additionally, Matrix metalloproteinases 2 and 9 are also implicated in a number of different forms of cancer.
The studies in progress at the School of Biotechnology, therefore, hold promise for utilizing these molecules as templates in the design of new drug candidates against targets involved in the complex multifactorial process of wound healing as well as different forms of cancer metastasis.